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1. Antisense oligonucleotides and diadenosine tetraphosphate notes, 1936-2009

Sub-Series Identifier: H MS c352
Scope and Contents: Consists of materials relating to Paul C. Zamecnik's research into antisense oligonucleotides and diadenosine tetraphosphate, as well as experiments relating to amino acids, such as his early research that showed the incorporation of C14 amino acid into the protein in rat liver slices, which led him to develop a cell-free system. Experiments from later in his career relate specifically to the discovery of antisense oligonucleotides and their therapeutic use and genetic repair potential for a...

1. Collected publications by subject, 1935-2011

Sub-Series Identifier: H MS c352
Scope and Contents: Consists of published scientific articles and reprints and manuscript drafts written by peers and colleagues, accompanied by related materials including research data and correspondence used as part of Zamecnik's career as a research scientist, arranged by subject matter. Topics include those broadly related to Zamecnik's research interests on topics of biochemistry, genetics, and gene repair, such as AIDS, Alzheimer's, antisense oligonucleotides, diadenosine tetraphosphate, prostate and...

1. Long ago on a day in spring, 2. An Introduction to Science - 1939, 1983 June-1987 January 13

File — Box 72: [Barcode: HC3IYJ], Folder: 23Identifier: H MS c352
Scope and Contents: Consists of manuscript drafts and related materials from Zamecnik's career as an author of scientific articles, both independently and with peers and colleagues. Some of the papers include annotated manuscript drafts, while others are publication-ready submissions. Most are accompanied by related correspondence, as well as notes, research data, and reprints of scientific articles by peers and colleagues. Topics include protein synthesis, transfer RNA and aminoacyl RNA transfer, the cell-free...

1) Pat Granahan and patents, 2) Patent related data, 3) AP4A patent itself, 4) Czech patents also CIP 1988 G, Z, and A (1 of 6), 1980 November-1993 March 17

File — Box 75: [Barcode: HC3J7A], Folder: 06Identifier: H MS c352
Scope and Contents:

File contains restricted Harvard University affiliate records.

1) Pat Granahan and patents, 2) Patent related data, 3) AP4A patent itself, 4) Czech patents also CIP 1988 G, Z, and A (2 of 6), 1980 November-1993 March 17

File — Box 75: [Barcode: HC3J7A], Folder: 07Identifier: H MS c352
Scope and Contents:

File contains restricted Harvard University affiliate records.

1) Pat Granahan and patents, 2) Patent related data, 3) AP4A patent itself, 4) Czech patents also CIP 1988 G, Z, and A (3 of 6), 1980 November-1993 March 17

File — Box 75: [Barcode: HC3J7A], Folder: 08Identifier: H MS c352
Scope and Contents:

File contains restricted Harvard University affiliate records.

1) Pat Granahan and patents, 2) Patent related data, 3) AP4A patent itself, 4) Czech patents also CIP 1988 G, Z, and A (4 of 6), 1980 November-1993 March 17

File — Box 75: [Barcode: HC3J7A], Folder: 09Identifier: H MS c352
Scope and Contents:

File contains restricted Harvard University affiliate records.

1) Pat Granahan and patents, 2) Patent related data, 3) AP4A patent itself, 4) Czech patents also CIP 1988 G, Z, and A (5 of 6), 1980 November-1993 March 17

File — Box 99: [Barcode: HC3IXL], Folder: 39Identifier: H MS c352
Scope and Contents:

File contains restricted Harvard University affiliate records.

1) Pat Granahan and patents, 2) Patent related data, 3) AP4A patent itself, 4) Czech patents also CIP 1988 G, Z, and A (6 of 6), 1980 November-1993 March 17

File — Box 75: [Barcode: HC3J7A], Folder: 10Identifier: H MS c352
Scope and Contents:

File contains restricted Harvard University affiliate records.

1) Transcriptional Tequlation, 2) Intercalation, 3) cell free transcription and 4) translation, protein synthesis, 5) Methylation effect (1 of 4), 1983-1993

File — Box 38: [Barcode: HC3J7S], Folder: 14Identifier: H MS c352
Scope and Contents: Consists of published scientific articles and reprints and manuscript drafts written by peers and colleagues, accompanied by related materials including research data and correspondence used as part of Zamecnik's career as a research scientist, arranged by subject matter. Topics include those broadly related to Zamecnik's research interests on topics of biochemistry, genetics, and gene repair, such as AIDS, Alzheimer's, antisense oligonucleotides, diadenosine tetraphosphate, prostate and...

1) Transcriptional Tequlation, 2) Intercalation, 3) cell free transcription and 4) translation, protein synthesis, 5) Methylation effect (2 of 4), 1983-1993

File — Box 38: [Barcode: HC3J7S], Folder: 15Identifier: H MS c352
Scope and Contents: Consists of published scientific articles and reprints and manuscript drafts written by peers and colleagues, accompanied by related materials including research data and correspondence used as part of Zamecnik's career as a research scientist, arranged by subject matter. Topics include those broadly related to Zamecnik's research interests on topics of biochemistry, genetics, and gene repair, such as AIDS, Alzheimer's, antisense oligonucleotides, diadenosine tetraphosphate, prostate and...

1) Transcriptional Tequlation, 2) Intercalation, 3) cell free transcription and 4) translation, protein synthesis, 5) Methylation effect (3 of 4), 1983-1993

File — Box 38: [Barcode: HC3J7S], Folder: 16Identifier: H MS c352
Scope and Contents: Consists of published scientific articles and reprints and manuscript drafts written by peers and colleagues, accompanied by related materials including research data and correspondence used as part of Zamecnik's career as a research scientist, arranged by subject matter. Topics include those broadly related to Zamecnik's research interests on topics of biochemistry, genetics, and gene repair, such as AIDS, Alzheimer's, antisense oligonucleotides, diadenosine tetraphosphate, prostate and...

1) Transcriptional Tequlation, 2) Intercalation, 3) cell free transcription and 4) translation, protein synthesis, 5) Methylation effect (4 of 4), 1983-1993

File — Box 38: [Barcode: HC3J7S], Folder: 17Identifier: H MS c352
Scope and Contents: Consists of published scientific articles and reprints and manuscript drafts written by peers and colleagues, accompanied by related materials including research data and correspondence used as part of Zamecnik's career as a research scientist, arranged by subject matter. Topics include those broadly related to Zamecnik's research interests on topics of biochemistry, genetics, and gene repair, such as AIDS, Alzheimer's, antisense oligonucleotides, diadenosine tetraphosphate, prostate and...

2. Collected publications by author, 1937-2011

Sub-Series Identifier: H MS c352
Scope and Contents: Consists of published scientific articles and reprints and manuscript drafts written by peers and colleagues, accompanied by related materials including research data and correspondence used as part of Zamecnik's career as a research scientist. Authors include the co-founder of Hybridon, Inc., Sudhir Agrawal; Mahlon Hoagland, the director of the Worcester Foundation for Experimental Biology and a colleague a Massachusetts General Hospital; as well as Michael Blackburn, Randy Burn, Bernard D....

2 Photos: Mahlon, Sis and Paul 1954; Our lab 1979 - Lily, 1954-2001 January 08

File — Box 94: [Barcode: HC3IXD], Folder: 06Identifier: H MS c352
Scope and Contents:

"Sis" likely refers to Mary Stephenson.

2. RNA and tRNA notes, 1953-2001

Sub-Series Identifier: H MS c352
Scope and Contents: Consists of materials relating to Paul C. Zamecnik's research into RNA and ribosomal structures, including that relating to the discovery of transfer RNA (called by Zamecnik soluble RNA or sRNA at the time of discovery) as well as microRNA later in his career. Research was performed during Zamecnik's time at the Collis P. Huntington Memorial Hospital, Massachusetts General Hospital, the Worcester Foundation for Experimental Biology, Hybridon, Inc., and ZATA Pharmaceuticals, Inc. Files...

3 H-Uridine and 3 H-Thymidine curves - Ki and Pim, 1974 July 12-1974 July 25

File — Box 21: [Barcode: HC3IYA], Folder: 08Identifier: H MS c352
Scope and Contents: Consists of materials relating to Paul C. Zamecnik's career as a researcher beyond the topics of antisense and RNA. This includes reference files from his time as a student, as well as research summaries, raw and analyzed research data, laboratory notebooks, research protocols and experiment procedures, and more general notes relating to laboratory research performed at Harvard Medical School, the Collis P. Huntington Memorial Hospital, Massachusetts General Hospital, the Worcester...

3. Other collected publications, 1910-2009

Sub-Series Identifier: H MS c352
Scope and Contents: Consists of published scientific articles, newspaper clippings, and related materials used in Zamecnik's research processes. Publications are on topics such as RNA and ribosomes, transfer RNA, antisense oligonucleotides, gene repair as related to mycobacterium tuberculosis, cystic fibrosis, HIV, malaria, Huntington's and Hodgkin's diseases, and the influenza virus, as well as other topics related to genetics and gene repair. Newspaper articles cover related topics in contemporary culture,...

3. Other research notes, 1931-2009

Sub-Series Identifier: H MS c352
Scope and Contents: Consists of materials relating to Paul C. Zamecnik's career as a researcher beyond the topics of antisense and RNA. This includes reference files from his time as a student, as well as research summaries, raw and analyzed research data, laboratory notebooks, research protocols and experiment procedures, and more general notes relating to laboratory research performed at Harvard Medical School, the Collis P. Huntington Memorial Hospital, Massachusetts General Hospital, the Worcester...

4 Blank Tapes Camera #2 T-11-13, 15, #14 not certain Interview with a participant (A), 1996 July

Item — Box 09: [Barcode: HC3J8C], Folder: 15Identifier: H MS c163
Scope and Contents:

Item is a taped recording of Zerka T. Moreno interviewing psychodrama participants. Item includes restricted patient information.

4 Blank Tapes Camera #2 T-11-13, 15, #14 not certain Interview with a participant (B), 1996 July

Item — Box 09: [Barcode: HC3J8C], Folder: 16Identifier: H MS c163
Scope and Contents:

Item is a taped recording of Zerka T. Moreno interviewing psychodrama participants. Item includes restricted patient information.

4 Blank Tapes Camera #2 T-11-13, 15, #14 not certain Interview with a participant (C), 1996 July

Item — Box 09: [Barcode: HC3J8C], Folder: 17Identifier: H MS c163
Scope and Contents:

Item is a taped recording of Zerka T. Moreno interviewing psychodrama participants. Item includes restricted patient information.

4 Blank Tapes Camera #2 T-11-13, 15, #14 not certain Interview with a participant (D), 1996 July

Item — Box 09: [Barcode: HC3J8C], Folder: 18Identifier: H MS c163
Scope and Contents:

Item is a taped recording of Zerka T. Moreno interviewing psychodrama participants. Item includes restricted patient information.

4 Blank Tapes Camera #2 T-11-13, 15, #14 not certain Interview with a participant (E), 1996 July

Item — Box 09: [Barcode: HC3J8C], Folder: 19Identifier: H MS c163
Scope and Contents:

Item is a taped recording of Zerka T. Moreno interviewing psychodrama participants. Item includes restricted patient information.

4 Blank Tapes Camera #2 T-11-13, 15, #14 not certain Interview with a participant (F), 1996 July

Item — Box 09: [Barcode: HC3J8C], Folder: 20Identifier: H MS c163
Scope and Contents:

Item is a taped recording of Zerka T. Moreno interviewing psychodrama participants. Item includes restricted patient information.